Dehydrocurdione, CAS 38230-32-9

Product Description: Dehydrocurdione, a zedoary-derived sesquiterpene, induces heme oxygenase (HO)-1, an antioxidative enzyme, in RAW 264.7 macrophages. Dehydrocurdione interacts with Keap1, resulting in Nrf2 translocation followed by activation of the HO-1 E2 enhancer. Dehydrocurdione suppresses lipopolysaccharide-induced NO release, a marker of inflammation. Anti-inflammatory activity[1][2].

Applications: COVID-19-immunoregulation

Formula: C15H22O2

References: [1]Yoshioka T, et al. Antiinflammatory potency of dehydrocurdione, a zedoary-derived sesquiterpene. Inflamm Res. 1998;47(12):476-481./[2]Ohnishi M, et al. Curcuma sp.-derived dehydrocurdione induces heme oxygenase-1 through a Michael reaction between its α, β-unsaturated carbonyl and Keap1. Phytother Res. 2018;32(5):892-897.

CAS Number: 38230-32-9

Molecular Weight: 234.33

Research Area: Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: Keap1-Nrf2;Reactive Oxygen Species

• Artikelnummer: MEXHY-N8160-10
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-N8160-10
• Green Labware: Nein
• Verpackungseinheit: 10mg
• Mengeneinheit: STK