Eicosapentaenoic Acid (sodium), CAS 73167-03-0

Product Description: Eicosapentaenoic Acid (EPA)sodium is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid sodium exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid sodium activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid sodium can promote relaxation of vascular smooth muscle cells and vasodilation[1][2][3].

Applications: Metabolism-sugar/lipid metabolism

Formula: C20H29NaO2

References: [1]Veronica Ceccarelli, et al.  Eicosapentaenoic acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. PLoS One. 2014 Jan 13;9(1):e85025./[2]Miaozhen Pan, et al. Dietary ω-3 polyunsaturated fatty acids are protective for myopia. Proc Natl Acad Sci U S A. 2021 Oct 26;118(43):e2104689118./[3]Shun-he Wang, et al. Endogenous omega-3 long-chain fatty acid biosynthesis from alpha-linolenic acid is affected by substrate levels, gene expression, and product inhibition. RSC Adv., 2017, 7, 40946-40951.

CAS Number: 73167-03-0

Molecular Weight: 324.43

Research Area: Metabolic Disease; Cardiovascular Disease; Cancer

Solubility: 10 mM in DMSO

Target: Endogenous Metabolite;Histone Demethylase

• Artikelnummer: MEXHY-W011269-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-W011269-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK