Emestrin, CAS 97816-62-1

Product Description: Emestrin is a mycotoxin originally isolated from E. striata that has antimicrobial, immunomodulatory, and cytotoxic activities. It is active against the fungi C. albicans and C. neoformans, as well as the bacteria E. coli, S. aureus, and methicillin-resistant S. aureus (MRSA; IC50s=3.94, 0.6, 2.21, 4.55, and 2.21 μg/mL, respectively).2 Emestrin is a chemokine (C-C motif) receptor 2 (CCR2) antagonist (IC50=5.4 μM in a radioligand binding assay using isolated human monocytes).3 Emestrin (0.1 μg/mL) induces apoptosis in HL-60 cells. It induces heart, thymus, and liver tissue necrosis in mice when administered at doses ranging from 18 to 30 mg/kg.

Applications: COVID-19-immunoregulation

Formula: C27H22N2O10S2

References: [1]Seya, et al. Structure and absolute configuration of emestrin, a new macrocyclic epidithiodioxopiperazine from Emericella striata. J. Chem. Soc. Chem. Commun. 10, 657-658 (1985).

CAS Number: 97816-62-1

Molecular Weight: 598.60

Research Area: Infection

Target: Others

• Artikelnummer: MEXHY-N8501-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-N8501-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK