Escitalopram, CAS 128196-01-0

Product Description: Escitalopram ((S)-Citalopram), the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram is an antidepressant for the research of major depression[1][2].

Applications: Neuroscience-Neuromodulation

Formula: C20H21FN2O

Citations: Mol Neurobiol. 2022 Mar 1./Phytomedicine. 2023 Dec, 121, 155083./J Clin Psychopharmacol. 2021 Jun 11.

References: [1]Zhang, P., et al., Structure-activity relationships for a novel series of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbon itrile) analogues at monoamine transporters. J Med Chem, 2010. 53(16): p. 6112-21./[2]Pastoor, D. and J. Gobburu, Clinical pharmacology review of escitalopram for the treatment of depression. Expert Opin Drug Metab Toxicol, 2014. 10(1): p. 121-8./[3]Wu C , et al. Escitalopram alleviates stress-induced Alzheimer's disease-like tau pathologies and cognitive deficits by reducing hypothalamic-pituitary-adrenal axis reactivity and insulin/GSK-3β signal pathway activity. Neurobiol Aging. 2018;67:137-147./[4]Cirrito JR, et al. Effect of escitalopram on Aβ levels and plaque load in an Alzheimer mouse model. Neurology. 2020;95(19):e2666-e2674.

CAS Number: 128196-01-0

Molecular Weight: 324.39

Compound Purity: 99.98

Research Area: Neurological Disease; Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Serotonin Transporter

• Artikelnummer: MEXHY-14258-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-14258-10.1
• Green Labware: Nein
• Verpackungseinheit: 10mM/1mL
• Mengeneinheit: STK