Gangliotetraose, CAS 75645-24-8

Product Description: Gangliotetraose (Gg4) is a tetrasccharide, exhibits major components including GM1 and its sialylated derivatives. GM1 facilitates efflux of nuclear Ca2+ and reduces the level of nuclear Ca2+ that characterizes the differentiated neuron. GM1 affects neuronal plasticity and repair mechanisms, as well as neurotrophin release in the brain[1][2].

Applications: Neuroscience-Neurodegeneration

Formula: C26H45NO21

References: [1]Okada H, et al. Complement-mediated cytolysis and azidothymidine are synergistic in HIV-1 suppression. Int Immunol. 1998 Jan;10(1):91-5. /[2]Ledeen RW, et al. The role of GM1 and other gangliosides in neuronal differentiation. Overview and new finding. Ann N Y Acad Sci. 1998 Jun 19;845:161-75.  /[3]Zakharova IO, et al. GM1 ganglioside activates ERK1/2 and Akt downstream of Trk tyrosine kinase and protects PC12 cells against hydrogen peroxide toxicity. Neurochem Res. 2014 Nov;39(11):2262-75.  /[4]Toffano G, et al. GM1 ganglioside stimulates the regeneration of dopaminergic neurons in the central nervous system. Brain Res. 1983 Feb 14;261(1):163-6. 

CAS Number: 75645-24-8

Molecular Weight: 707.63

Research Area: Neurological Disease

Solubility: 10 mM in DMSO

Target: Others

• Artikelnummer: MEXHY-N10512-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-N10512-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK