Garcinone C, CAS 76996-27-5

Product Description: Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, while efficiently inhibiting the expression levels of cyclin B1, cyclin D1, cyclin E2, cdc2, Stat3 and CDK7. Garcinone C significantly inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner[1].

Applications: Cancer-Kinase/protease

Formula: C23H26O7

References: [1]Xia Y, et al. Garcinone C exerts antitumor activity by modulating the expression of ATR/Stat3/4E BP1 in nasopharyngeal carcinoma cells. Oncol Rep. 2018 Mar;39(3):1485-1493.

CAS Number: 76996-27-5

Molecular Weight: 414.45

Compound Purity: 99.66

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: ATM/ATR;CDK;STAT

• Artikelnummer: MEXHY-N6954-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-N6954-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK