Guanfu base A, CAS 1394-48-5

Product Description: Guanfu base A is an antiarrhythmic alkaloid isolated from Aconitum coreanum and is a potent noncompetitive CYP2D6 inhibitor, with a Ki of 1.20 μM in human liver microsomes (HLMs) and a Ki of 0.37 μM for the human recombinant form (rCYP2D6). Guanfu base A is also a potent competitive inhibitor of CYP2D in monkey (Ki of 0.38 μM) and dog (Ki of 2.4 μM) microsomes[1]. Guanfu base A also inhibits HERG channel current[2].

Applications: Neuroscience-Neuromodulation

Formula: C24H31NO6

References: [1]Sun J, et al. Guanfu base A, an antiarrhythmic alkaloid of Aconitum coreanum, Is a CYP2D6 inhibitor of human, monkey, and dog isoforms. Drug Metab Dispos. 2015 May;43(5):713-24./[2]Huang X, et al. Comparative effects of Guanfu base A and Guanfu base G on HERG K+ channel. J Cardiovasc Pharmacol. 2012 Jan;59(1):77-83.

CAS Number: 1394-48-5

Molecular Weight: 429.51

Compound Purity: 98.10

Research Area: Cardiovascular Disease

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Potassium Channel

• Artikelnummer: MEXHY-N1483-10
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-N1483-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK