Product Description: HMBPP (E-4-Hydroxy-3-methyl-but-2-enyl diphosphate) is an activator for human Vγ9/Vδ2 T cells. HMBPP exhibits phagostimulant property in mosquitos[1][2].
Applications: COVID-19-immunoregulation
Formula: C5H12O8P2
References: [1]Hintz M, et al., Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gammadelta T cells in Escherichia coli. FEBS Lett. 2001 Dec 7;509(2):317-22./[2]Stromsky VE, et al., Plasmodium metabolite HMBPP stimulates feeding of main mosquito vectors on blood and artificial toxic sources. Commun Biol. 2021 Oct 7;4(1):1161.
CAS Number: 396726-03-7
Molecular Weight: 262.09
Research Area: Infection; Inflammation/Immunology
Solubility: 10 mM in DMSO
Target: Nuclear Factor of activated T Cells (NFAT)