Homobutein, CAS 34000-39-0

Product Description: Homobutein a natural chalcones (can be found in many medicinal plants, fruits, vegetables, spices and nuts), is a potent HDACs/NF-κB dual inhibitor with IC50s of 190 and 38 μM, respectively. Homobutein also a chelator of iron (II and III) cations, shows various activities, including anticancer, anti-inflammatory, antiparasite and antioxidation[1][2][3][4].

Applications: COVID-19-anti-virus

Formula: C16H14O5

References: [1]Orlikova B, et al. Natural chalcones as dual inhibitors of HDACs and NF-κB. Oncol Rep. 2012 Sep;28(3):797-805./[2]Adeyemi OS, et al. In Vitro Screening to Identify Anti-Toxoplasma Compounds and In Silico Modeling for Bioactivities and Toxicity. Yale J Biol Med. 2019 Sep 20;92(3):369-383./[3]Yenesew A, et al. Anti-plasmodial flavonoids from the stem bark of Erythrina abyssinica. Phytochemistry. 2004 Nov;65(22):3029-32./[4]Serobatse K, et al. Antioxidant and antimalarial properties of butein and homobutein based on their ability to chelate iron (II and III) cations: a DFT study in vacuo and in solution. European Food Research and Technology, 2016, 242(1): 71-90.

CAS Number: 34000-39-0

Molecular Weight: 286.28

Research Area: Cancer; Infection; Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: HDAC;NF-κB;Parasite

• Artikelnummer: MEXHY-N8707-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-N8707-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK