Isosilybin A, CAS 142796-21-2

Product Description: Isosilybin A, a flavonolignan isolated from silymarin, has anti-prostate cancer (PCA) activity. Isosilybin A inhibits proliferation and induces G1 phase arrest and apoptosis in cancer cells, which activates apoptotic machinery in PCA cells via targeting Akt-NF-κB-androgen receptor (AR) axis[1][2].

Applications: Cancer-programmed cell death

Formula: C25H22O10

References: [1]Deep G, et al. Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostatecancer LNCaP and 22Rv1 cells. Carcinogenesis. 2007 Jul;28(7):1533-42./[2]Deep G, et al. Isosilybin A induces apoptosis in human prostate cancer cells via targeting Akt, NF-κB, and androgen receptor signaling. Mol Carcinog. 2010 Oct;49(10):902-12.

CAS Number: 142796-21-2

Molecular Weight: 482.44

Compound Purity: 99.63

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Apoptosis

• Artikelnummer: MEXHY-N7043-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-N7043-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK