Isosilybin B, CAS 142796-22-3

Product Description: Isosilybin B, a flavonolignan isolated from Silybum marianum, has anti-prostate cancer (PCA) activity via inhibiting proliferation and inducing G1 phase arrest and apoptosis. Isosilybin B causes androgen receptor (AR) degradation[1][2].

Applications: Cancer-programmed cell death

Formula: C25H22O10

References: [1]Deep G, et al. Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostatecancer LNCaP and 22Rv1 cells. Carcinogenesis. 2007 Jul;28(7):1533-42./[2]Deep G, et al. Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway. Oncogene. 2008 Jun 26;27(28):3986-98.

CAS Number: 142796-22-3

Molecular Weight: 482.44

Compound Purity: 99.32

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Androgen Receptor;Apoptosis

• Artikelnummer: MEXHY-N7045-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-N7045-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK