Lapachol, CAS 84-79-7

Product Description: Lapachol, a natural naphthoquinone, is an orally active, potent DHODH inhibitor. Lapachol has immunosuppressive activity on lymphocytes through its direct ability to block DHODH activity and inhibit pyrimidine synthesis. Lapachol is a vitamin K antagonist with antitumor activity and can inhibit DNA and RNA synthesis in neoplastic cells. Lapachol has anti-Leishmania activity[1][2][3].

Applications: Cancer-programmed cell death

Formula: C15H14O3

References: [1]Raphael S Peres, et al. Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis. Arthritis Res Ther. 2017 Mar 7;19(1):47./[2]Masayo Maeda, et al. Promotion or suppression of experimental metastasis of B16 melanoma cells after oral administration of lapachol. Toxicol Appl Pharmacol. 2008 Jun 1;229(2):232-8./[3]Iasmin Aparecida Cunha Araújo, et al. Efficacy of lapachol on treatment of cutaneous and visceral leishmaniasis. Exp Parasitol. 2019 Apr:199:67-73.

CAS Number: 84-79-7

Molecular Weight: 242.27

Compound Purity: 99.06

Research Area: Cancer; Infection; Inflammation/Immunology

Solubility: DMSO : 66.67 mg/mL (ultrasonic)

Target: Dihydroorotate Dehydrogenase;DNA/RNA Synthesis;Parasite

• Artikelnummer: MEXHY-N6961-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-N6961-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK