(-)-Latifolin, CAS 10154-42-4

Product Description: (-)-Latifolin, a flavonoid, induces apoptotic cell death by targeting PI3K/AKT/mTOR/p70S6K signaling. (-)-Latifolin significantly inhibits the cell proliferation of oral squamous cell carcinoma (OSCC), and causes the anti-metastatic activities by effectively blocking cell migration, invasion, and adhesion via the inactivation of FAK/Src. (-)-Latifolin suppresses autophagic-related proteins and autophagosome formation. (-)-Latifolin inhibits necroptosis by dephosphorylating necroptosis-regulatory proteins (RIP1, RIP3, and MLKL). (-)-Latifolin has beneficial effects on anti-aging, anti-carcinogenic, anti-inflammatory, and cardio-protective activities[1].

Applications: Cancer-Kinase/protease

Formula: C17H18O4

References: [1]Hyung-Mun Yun, et al. Latifolin, a Natural Flavonoid, Isolated from the Heartwood of Dalbergia odorifera Induces Bioactivities through Apoptosis, Autophagy, and Necroptosis in Human Oral Squamous Cell Carcinoma. Int J Mol Sci. 2022 Nov 7;23(21):13629.

CAS Number: 10154-42-4

Molecular Weight: 286.32

Research Area: Cancer; Inflammation/Immunology; Cardiovascular Disease

Solubility: 10 mM in DMSO

Target: Apoptosis;Autophagy;Necroptosis;PI3K

• Artikelnummer: MEXHY-N8380-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-N8380-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK