Marein, CAS 535-96-6

Product Description: Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein is a HDAC inhibitor with an IC50 of 100 μM. Marein has beneficial antioxidative, antihypertensive, antihyperlipidemic and antidiabetic effects[1][2][3].

Applications: Metabolism-sugar/lipid metabolism

Formula: C21H22O11

References: [1] Baoping Jiang, et al. Protective effects of marein on high glucose-induced glucose metabolic disorder in HepG2 cells. Phytomedicine. 2016 Aug 15;23(9):891-900./[2]Baoping Jiang, et al. Marein protects against methylglyoxal-induced apoptosis by activating the AMPK pathway in PC12 cells. Free Radic Res. 2016;50(11):1173-1187./[3]B Orlikova, et al. Natural chalcones as dual inhibitors of HDACs and NF-κB. Oncol Rep. 2012 Sep;28(3):797-805.

CAS Number: 535-96-6

Molecular Weight: 450.39

Compound Purity: 99.71

Research Area: Metabolic Disease; Neurological Disease; Cardiovascular Disease

Solubility: DMSO : 25 mg/mL (ultrasonic)

Target: AMPK;HDAC

• Artikelnummer: MEXHY-N7676-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-N7676-10.1
• Verpackungseinheit: 10mM/1mL
• Mengeneinheit: STK