Neoaureothin, CAS 59795-94-7

Product Description: Neoaureothin is a bacterial metabolite that has been found in Streptomyces. It is an androgen receptor (AR) antagonist that inhibits binding of dihydrotestosterone (DHT) to ARs (IC50=13 μM) and inhibits DHT-induced expression of prostate-specific antigen in LNCaP cells (IC50=1.75 nM). Neoaureothin is cytotoxic to A549, HCT116, and HepG2 cells (IC50s=34.3, 47, and 37.2 μg/mL, respectively). It also has nematocidal activity against the pine wood nematode B. xylophilus (LC50=0.84 μg/mL) and increases survival of P. densiflora trees inoculated with B. xylophilus.

Applications: COVID-19-immunoregulation

Formula: C28H31NO6

References: [1]Kawamura, et al. Isolation and structure elucidation of a novel androgen antagonist, arabilin, produced by Streptomyces sp. MK756-CF1. J. Antibiot. (Tokyo) 63(10), 601-605 (2010).

CAS Number: 59795-94-7

Molecular Weight: 477.55

Research Area: Infection

Target: Bacterial

• Artikelnummer: MEXHY-N8504-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-N8504-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK