Neriifolin, CAS 466-07-9

Product Description: Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na+, K+-ATPase. Neriifolin can target beclin 1, inhibits the formation of LC3-associated phagosomes and ameliorates experimental autoimmune encephalomyelitis (EAE) development. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells[1][2.

Applications: COVID-19-immunoregulation

Formula: C30H46O8

References: [1]Keller CW, et al. ATG-dependent phagocytosis in dendritic cells drives myelin-specific CD4+ T cell pathogenicity during CNS inflammation. Proc Natl Acad Sci U S A. 2017;114(52):E11228-E11237./[2]Zhao Q, et al. Neriifolin from seeds of Cerbera manghas L. induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Fitoterapia. 2011;82(5):735-741.

CAS Number: 466-07-9

Molecular Weight: 534.68

Compound Purity: 99.43

Research Area: Cancer; Inflammation/Immunology

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Apoptosis;Atg8/LC3;Beclin1;Na+/K+ ATPase

• Artikelnummer: MEXHY-N8441-10
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-N8441-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK