Orotic acid (zinc), CAS 68399-76-8

Product Description: Orotic acid (zinc), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid (zinc) is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid (zinc) can induce hepatic steatosis and hepatomegaly in rats[1][2][3].

Applications: Metabolism-protein/nucleotide metabolism

Formula: C5H4N2O4Zn0.5

References: [1]Löffler M, et, al. Orotate (orotic acid): An essential and versatile molecule. Nucleosides Nucleotides Nucleic Acids./[2]Staretz-Chacham O, et, al. The role of orotic acid measurement in routine newborn screening for urea cycle disorders. J Inherit Metab Dis. 2020 Nov 15./[3]Durschlag RP, et, al. Orotic acid-induced metabolic changes in the rat. J Nutr. 1980 Apr;110(4):816-21.

CAS Number: 68399-76-8

Molecular Weight: 188.79

Compound Purity: 98.0

Research Area: Metabolic Disease

Solubility: 10 mM in DMSO

Target: Endogenous Metabolite;Nucleoside Antimetabolite/Analog

• Artikelnummer: MEXHY-N0157A-100
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-N0157A-100
• Green Labware: Nein
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK