Palmatine, CAS 3486-67-7

Product Description: Palmatine is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC50s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC50 of 96 μM. Palmatine shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities[1][2][3][4][5].

Applications: COVID-19-immunoregulation

Formula: C21H22NO4

Citations: Drug Dev Res. 2022 Aug 17./Int Immunopharmacol. 2022 Feb 9;106:108583./Oxid Med Cell Longev. 2021 Mar 13./Biol Res. 2020 Sep 14;53(1):39./J Ethnopharmacol. 2023 Sep 27:117238./Molecules. 2024 May 14.

References: [1]Liu X, et al. Palmatine induces G2/M phase arrest and mitochondrial-associated pathway apoptosis in colon cancer cells by targeting AURKA. Biochem Pharmacol. 2020 May;175:113933./[2]Lee WC, et al. Palmatine attenuates D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure in mice. Food Chem Toxicol. 2010 Jan;48(1):222-8./[3]Jia F, et al. Identification of palmatine as an inhibitor of West Nile virus. Arch Virol. 2010 Aug;155(8):1325-9./[4]Dhingra D, et al. Memory-enhancing activity of palmatine in mice using elevated plus maze and morris water maze. Adv Pharmacol Sci. 2012;2012:357368./[5]Long J, et al. Palmatine: A review of its pharmacology, toxicity and pharmacokinetics. Biochimie. 2019 Jul;162:176-184./[6]Zhang XJ, et al. Palmatine ameliorated murine colitis by suppressing tryptophan metabolism and regulating gut microbiota.Pharmacol Res. 2018 Nov;137:34-46.

CAS Number: 3486-67-7

Molecular Weight: 352.40

Research Area: Cancer; Infection; Metabolic Disease; Inflammation/Immunology; Neurological Disease

Solubility: 10 mM in DMSO

Target: Apoptosis;Aurora Kinase;Bacterial;Indoleamine 2,3-Dioxygenase (IDO);Parasite;Virus Protease

• Artikelnummer: MEXHY-N0110A-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-N0110A-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK