PCSK9-IN-28

Product Description: PCSK9-IN-28 (Compound C11) is a PCSK9 inhibitor that can be isolated from Euphorbia esula. By binding to HNF1α, PCSK9-IN-28 inhibits PCSK9 transcription by binding to HNF1α and affecting its nuclear distribution, thereby enhancing LDLR and promoting LDL uptake. PCSK9-IN-28 exhibits significant lipid-lowering activity in the high-fat diet (HFD) mouse model and can be used in the study of hyperlipidemia[1].

Applications: Neuroscience-Neuromodulation

Formula: C28H38O10

References: [1]Chen T, et al. Novel Jatrophane Diterpenoids from Euphorbia esul a Promotes Lipid Clearance by Transcriptional Regulation of PCSK9[J]. Journal of Medicinal Chemistry, 2024.

Molecular Weight: 534.60

Research Area: Cardiovascular Disease

Target: PCSK9

• Artikelnummer: MEXHY-N13083-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-N13083-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK