Product Description: Talaroterphenyl A (compound 1) is a p-terphenyl derivative present in the mangrove sediment-derived fungus Talaromyces sp. SCSIO 41412, which exhibits phosphodiesterase 4 (PDE4) inhibitory activity (IC50=1.2 μM). Talaroterphenyl A also exhibits anti-inflammatory and anti-fibrotic activities, significantly reducing the mRNA levels of pro-inflammatory cytokines IL-6, TNF-α, and IL-1β[1].
Formula: C22H20O5
References: [1]Cai J, et al. Discovery of Oxidized p-Terphenyls as Phosphodiesterase 4 Inhibitors from Marine-Derived Fungi[J]. Journal of Natural Products, 2024.
Molecular Weight: 364.39
Research Area: Inflammation/Immunology; Others
Target: Phosphodiesterase (PDE)