Trabectedin, CAS 114899-77-3

Product Description: Trabectedin (Ecteinascidin 743; ET-743) is a tetrahydroisoquinoline alkaloid with potent antitumor activity. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF-7 and MDA-MB-453 cells. Trabectedin has the potential for soft tissue sarcoma and ovarian cancer research[1][2][3].

Applications: Cancer-programmed cell death

Formula: C39H43N3O11S

References: [1]Takahashi N, et al. Sequence-dependent synergistic cytotoxicity of ecteinascidin-743 and NSC 125973 in human breast cancer cell linesin vitro and in vivo. Cancer Res. 2002 Dec 1;62(23):6909-15./[2]Germano G, et al. Antitumor and anti-inflammatory effects of trabectedin on human myxoid liposarcoma cells. Cancer Res. 2010 Mar 15;70(6):2235-44./[3]Atmaca H, et al. A diverse induction of apoptosis by trabectedin in MCF-7 (HER2-/ER+) and MDA-MB-453 (HER2+/ER-) breast cancer cells. Toxicol Lett. 2013 Jun 20;221(2):128-136.

CAS Number: 114899-77-3

Molecular Weight: 761.84

Compound Purity: 99.83

Research Area: Cancer; Inflammation/Immunology

Solubility: DMSO : 33.33 mg/mL (ultrasonic)

Target: Apoptosis;Reactive Oxygen Species

• Artikelnummer: MEXHY-50936-100
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-50936-100
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK