Tubulysin F, CAS 368870-67-1

Tubulysin F, CAS 368870-67-1
Artikelnummer
MEXHY-N7049-5
Verpackungseinheit
5mg
Hersteller
MedChemExpress

Verfügbarkeit: wird geladen...
Preis wird geladen...
Product Description: Tubulysin F is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin F can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin F displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. Tubulysin F inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis[1][2].

Applications: Cancer-programmed cell death

Formula: C41H61N5O9S

References: [1]Vlahov IR, et al. Acid mediated formation of an N-acyliminium ion from tubulysins: a new methodology for the synthesis of natural tubulysins and their analogs. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6778-81./[2]Kubicek K, et al. The tubulin-bound structure of the antimitotic drug tubulysin. Angew Chem Int Ed Engl. 2010 Jun 28;49(28):4809-12.

CAS Number: 368870-67-1

Molecular Weight: 800.02

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: ADC Cytotoxin;Microtubule/Tubulin
Mehr Informationen
Artikelnummer MEXHY-N7049-5
Hersteller MedChemExpress
Hersteller Artikelnummer HY-N7049-5
Green Labware Nein
Verpackungseinheit 5mg
Mengeneinheit STK
Produktinformation (PDF) Download
MSDS (PDF)
×