Tubulysin M, CAS 936691-46-2

Product Description: Tubulysin M is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin M can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin M displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. Tubulysin M inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis[1][2][3].

Applications: Cancer-programmed cell death

Formula: C38H57N5O7S

References: [1]Wang Y, et al. Structural Insights into the Pharmacophore of Vinca Domain Inhibitors of Microtubules. Mol Pharmacol. 2016 Feb;89(2):233-42./[2]Kubicek K, et al. The tubulin-bound structure of the antimitotic drug tubulysin. Angew Chem Int Ed Engl. 2010 Jun 28;49(28):4809-12./[3]Vlahov IR, et al. Acid mediated formation of an N-acyliminium ion from tubulysins: a new methodology for the synthesis of natural tubulysins and their analogs. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6778-81.

CAS Number: 936691-46-2

Molecular Weight: 727.95

Compound Purity: 96.0

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: ADC Cytotoxin;Microtubule/Tubulin

• Artikelnummer: MEXHY-N7053-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-N7053-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK