Uridine-5'-diphosphate disodium salt, CAS 27821-45-0

Product Description: Uridine-5'-diphosphate disodium salt is a potent, selective P2Y6 receptor native agonist (EC50=300 nM; pEC50=6.52 for human P2Y6 receptor). Uridine-5'-diphosphate disodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis[1][2].

Applications: COVID-19-anti-virus

Formula: C9H12N2Na2O12P2

References: [1]Edyta Gendaszewska-Darmach, et al. Nucleoside 5'-O-monophosphorothioates as modulators of the P2Y14 receptor and mast cell degranulation. Oncotarget. 2016 Oct 25;7(43):69358-69370./[2]Zainab S B Abbas, et al. UDP-sugars activate P2Y 14 receptors to mediate vasoconstriction of the porcine coronary artery. Vascul Pharmacol. 2018 Apr;103-105:36-46./[3]Jacobson KA, et al. Development of selective agonists and antagonists of P2Y receptors. Purinergic Signal. 2009 Mar;5(1):75-89./[4]Kim B, et al. Uridine 5'-diphosphate induces chemokine expression in microglia and astrocytes through activation of the P2Y6 receptor. J Immunol. 2011 Mar 15;186(6):3701-9.

CAS Number: 27821-45-0

Molecular Weight: 448.12

Compound Purity: 99.0

Research Area: Metabolic Disease; Inflammation/Immunology

Solubility: DMSO : < 1 mg/mL/H2O : 100 mg/mL (ultrasonic)

Target: DNA/RNA Synthesis;Endogenous Metabolite;P2Y Receptor

• Artikelnummer: MEXHY-W010832-100
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-W010832-100
• Green Labware: Nein
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK