Vinorelbine, CAS 71486-22-1

Product Description: Vinorelbine is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.

Applications: Cancer-programmed cell death

Formula: C45H54N4O8

Citations: Am J Cancer Res. 2021 Apr 15;11(4):1428-1445./Biochem Pharmacol. 2020 May;175:113865./Cancers (Basel). 2021, 13(13), 3323./J Bone Oncol. October 2021, 100391./Microsyst Nanoeng. 7, 38 (2021)./Biochem Biophys Res Commun. 2020 May 21;526(1):154-157./Cell Mol Immunol. 2023 Jan;20(1):51-64./EBioMedicine. 2021 Aug 5;70:103510./iScience. 6 September 2022, 105081./Sci Adv. 2023 Jun 2;9(22):eadc9273.

References: [1]Ngan VK, et al. Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic Vinca alkaloids vinorelbine and its newer derivative vinflunine. Mol Pharmacol. 2001 Jul;60(1):225-32./[2]Pierro JA, et al. Phase I clinical trial of vinorelbine in tumor-bearing cats. J Vet Intern Med. 2013 Jul-Aug;27(4):943-8./[3]Poirier VJ, et al. Toxicity, dosage, and efficacy of vinorelbine (Navelbine) in dogs with spontaneous neoplasia. J Vet Intern Med. 2004 Jul-Aug;18(4):536-9./[4]Liu XM, et al. Unique induction of p21(WAF1/CIP1)expression by vinorelbine in androgen-independent prostate cancer cells. Br J Cancer. 2003 Oct 20;89(8):1566-73.

CAS Number: 71486-22-1

Molecular Weight: 778.93

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Autophagy;Microtubule/Tubulin

• Artikelnummer: MEXHY-12053-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-12053-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK