Wedelolactone, CAS 524-12-9

Product Description: Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibits the IKK Complex. Wedelolactone also inhibits 5-lipoxygenase (5-Lox) with an IC50 of 2.5 μM. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Wedelolactone can extract from Eclipta alba, and it can be used for the research of cancer[1][2][3].

Applications: Cancer-programmed cell death

Formula: C16H10O7

References: [1]Kobori M, et al. Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex. Cell Death Differ. 2004 Jan;11(1):123-30./[2]Sarveswaran S, et al. Wedelolactone, a medicinal plant-derived coumestan, induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Int J Oncol. 2012 Dec;41(6):2191-9./[3]Liu YQ, et al. Wedelolactone enhances osteoblastogenesis by regulating Wnt/β-catenin signaling pathway but suppresses osteoclastogenesis by NF-κB/c-fos/NFATc1 pathway. Sci Rep. 2016 Aug 25;6:32260.

CAS Number: 524-12-9

Molecular Weight: 314.25

Compound Purity: 99.91

Research Area: Cancer; Inflammation/Immunology

Solubility: DMSO : 125 mg/mL (ultrasonic)

Target: Apoptosis;Caspase;Lipoxygenase

• Artikelnummer: MEXHY-N0551-50
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-N0551-50
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK