Formulation: A solid
Formal Name: N-acetyl-L-isoleucylglycyl-L-lysyl-L-α-glutamyl-L-phenylalanyl-L-lysyl-L-arginyl-L-isoleucyl-L-valyl-L-α-glutamyl-L-arginyl-L-isoleucyl-L-lysyl-L-arginyl-L-phenylalanyl-L-leucyl-L-arginyl-L-α-glutamyl-L-leucyl-L-valyl-L-arginyl-L-prolyl-L-leucyl-L-argininamide, trifluoroacetate salt
Purity: ≥95%
Formula Markup: C142H246N46O31 • XCF3COOH
Formula Weight: 3093,8
Shelf life (days): 1460
Notes: OP-145 is a synthetic antimicrobial peptide and derivative of the antimicrobial peptide LL-37 (Item No. 24461).{51401} It is active against E. coli, P. aeruginosa, C. albicans, and A. niger (MICs = 2, 3, 6, and 18 µM, respectively). Poly(lactic-co-glycolic acid) (PLGA) microspheres containing OP-145 prevent biofilm formation in a mouse model of bone infection induced by surgical femoral fracture followed by bacterial inoculation at the fracture site.{51402}