4-1BB/TNFRSF9, Mouse (HEK293, His)

Product Description: 4-1BB (CD137; TNFRSF9), a receptor of TNFSF9/4-1BBL, belongs to the tumor necrosis factor (TNF) receptor superfamily[1]. 4-1BB is helpful for T cell activation and development, and also induces peripheral mononuclear cell proliferation and migration to the tumor microenvironment[2]. 4-1BB is also involved in enhancing Nrf2 and NF-κB pathway mediated apoptosis of endothelial cells[3]. Mouse 4-1BB protein is a surface glycoprotein with a transmembrane domain (188-208 a.a.). 4-1BB/TNFRSF9 Protein, Mouse (HEK293, His) is the extracellular part (V24-L187) of 4-1BB protein, produced by HEK293 cells with C-terminal His-tag.

Formula: 21942(Gene_ID)P20334/NP_001070977 (V24-L187)(Accession)

References: [1]Ye L, et al. CD137, an attractive candidate for the immunotherapy of lung cancer. Cancer Sci. 2020 May;111(5):1461-1467./[2]Jiang P, et al. CD137 promotes bone metastasis of breast cancer by enhancing the migration and osteoclast differentiation of monocytes/macrophages. Theranostics. 2019 May 9;9(10):2950-2966./[3]Geng T, et al. CD137 Signaling Promotes Endothelial Apoptosis by Inhibiting Nrf2 Pathway, and Upregulating NF-κB Pathway. Mediators Inflamm. 2020 Jun 6;2020:4321912./[4]Pauly S, et al. CD137 is expressed by follicular dendritic cells and costimulates B lymphocyte activation in germinal centers. J Leukoc Biol. 2002 Jul;72(1):35-42.

Molecular Weight: Approximately 19.00 kDa

Compound Purity: 96.00

• Artikelnummer: MEXHY-P72884-10UG
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-P72884-10UG
• Green Labware: Nein
• Verpackungseinheit: 10 μg
• Mengeneinheit: STK