Product Description: α-Helical CRF(9-41) TFA is a competitive CRF2 receptor antagonist with KB of ~100 nM. α-Helical CRF(9-41) TFA is also a partial agonist of CRF1 receptor with an EC50 of 140 nM[1][2].
Applications: Neuroscience-Neuromodulation
Formula: C168H275F3N46O55S2
References: [1]Sonia Tucci, et al. Corticotropin releasing factor antagonist, alpha-helical CRF(9-41), reverses nicotine-induced conditioned, but not unconditioned, anxiety. Psychopharmacology (Berl). 2003 May;167(3):251-6./[2]Smart D, et al. Characterisation using microphysiometry of CRF receptor pharmacology. Eur J Pharmacol. 1999 Aug 27;379(2-3):229-35.
Molecular Weight: 3940.42
Compound Purity: 99.72
Research Area: Neurological Disease
Solubility: H2O : 1.82 mg/mL (ultrasonic;adjust pH to 3 with HCl)
Target: CRFR