Apelin-36(human) (TFA)

Product Description: Apelin-36(human) TFA is an endogenous orphan G protein-coupled receptor APJ agonist, with an EC50 of 20 nM. Apelin-36(human) TFA shows high affinity to human APJ receptors expressed in HEK 293 cells (pIC550=8.61). Apelin-36(human) TFA has been linked to two major types of biological activities: cardiovascular and metabolic. Apelin-36(human) TFA inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ[1][2][3][4].

Applications: Metabolism-protein/nucleotide metabolism

Formula: C186H298F3N69O45S

References: [1]Tatemoto K, Hosoya M, Habata Y, et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun. 1998;251(2):471-476./[2]Medhurst AD, Jennings CA, Robbins MJ, et al. Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin. J Neurochem. 2003;84(5):1162-1172./[3]Zou MX, Liu HY, Haraguchi Y, Soda Y, Tatemoto K, Hoshino H. Apelin peptides block the entry of human immunodeficiency virus (HIV). FEBS Lett. 2000;473(1):15-18.

Molecular Weight: 4309.85

Compound Purity: 98.11

Research Area: Infection; Metabolic Disease; Cardiovascular Disease

Solubility: 10 mM in DMSO

Target: Apelin Receptor (APJ);HIV

• Artikelnummer: MEXHY-P1064A-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-P1064A-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK