Azurin p28 peptide (TFA)

Product Description: Azurin p28 peptide TFA is a tumor-penetrated antitumor peptide. Azurin p28 peptide TFA redues proteasomal degradation of p53 through formation of a p28: p53 complex. Azurin p28 peptide TFA induces apoptosis or cell cycle arrest. Azurin p28 peptide TFA inhibits p53-positive tumor growths. Azurin p28 peptide TFA shows antiangiogenic effect by inhibiting phosphorylation of VEGFR-2, FAK and Akt[1][2][3].

Applications: Cancer-programmed cell death

Formula: C122H197N31O47S2.xCF3COOH

References: [1]Mehta RR, et al. A cell penetrating peptide derived from azurin inhibits angiogenesis and tumor growth by inhibiting phosphorylation of VEGFR-2, FAK and Akt. Angiogenesis. 2011 Sep;14(3):355-69./[2]Jia L, et al. Preclinical pharmacokinetics, metabolism, and toxicity of azurin-p28 (NSC745104) a peptide inhibitor of p53 ubiquitination. Cancer Chemother Pharmacol. 2011 Aug;68(2):513-24./[3]Yamada T, et al. A peptide fragment of azurin induces a p53-mediated cell cycle arrest in human breast cancer cells. Mol Cancer Ther. 2009 Oct;8(10):2947-58.

Molecular Weight: 2914.18(free base)

Research Area: Cancer

Target: Apoptosis;MDM-2/p53

• Artikelnummer: MEXHY-P5910A-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-P5910A-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK