BMS-470539, CAS 457893-92-4

Product Description: BMS-470539 is a synthetic MC-1R agonist with potent anti-inflammatory properties. BMS-470539 selectively activates human and murine MC-1R with EC50 values ??of 16.8 nM and 11.6 nM, respectively. In vitro studies have shown that BMS-470539 is able to dose-dependently inhibit TNF-alpha-induced NF-kB activation in human melanoma cells expressing MC-1R. In vivo, subcutaneous injection of BMS-470539 into BALB/c mice effectively inhibited LPS-induced TNF-alpha production with an ED50 of approximately 10 μmol/kg and a pharmacodynamic half-life of approximately 8 hours. It also significantly reduced leukocyte infiltration in a lung inflammation model and attenuated paw swelling in a delayed-type hypersensitivity model, highlighting its efficacy as an anti-inflammatory agent through MC-1R modulation[1].

Applications: Cancer-programmed cell death

Formula: C32H41N5O4

References: [1]A selective small molecule agonist of the melanocortin-1 receptor inhibits lipopolysaccharide-induced cytokine accumulation and leukocyte infiltration in mice

CAS Number: 457893-92-4

Molecular Weight: 559.70

Research Area: cancer

Solubility: 10 mM in H2O

Target: Melanocortin Receptor

• Artikelnummer: MEXHY-15616-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-15616-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK