Branebrutinib, CAS 1912445-55-6

Product Description: Branebrutinib (BMS-986195) is a highly potent, selective covalent, irreversible inhibitor of Bruton’s tyrosine kinase (BTK), with an IC50 of 0.1 nM[1][2]. Branebrutinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Applications: Cancer-Kinase/protease

Formula: C20H23FN4O2

References: [1]JR Burke, et al. BMS-986195 Is a Highly Selective and Rapidly Acting Covalent Inhibitor of Bruton’s Tyrosine Kinase with Robust Efficacy at Low Doses in Preclinical Models of RA and Lupus Nephritis. 2017 ACR/ARHP Annual Meeting, September 18, 2017./[2]Watterson SH, et al. Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton's Tyrosine Kinase (BTK). J Med Chem. 2019 Apr 11;62(7):3228-3250.

CAS Number: 1912445-55-6

Molecular Weight: 370.42

Compound Purity: 99.82

Research Area: Cancer

Solubility: DMSO : ≥ 150 mg/mL

Target: Btk

• Artikelnummer: MEXHY-112161-25
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-112161-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK