CD127/IL-7RA, Cynomolgus (HEK293, His)

Product Description: IL-7RA (also known as CD127) is a type 1 membrane glycoprotein folded to bind and mediate the action of IL7 and other alpha helical cytokines. IL-7RA is mainly expressed by cells of the lymphoid lineage. IL-7RA also acts as a receptor for thymic stromal lymphopoietin (TSLP). CD127/IL-7RA Protein, Cynomolgus (HEK293, His) is produced in HEK293 cells with a C-Terminal His-tag. It consists of 235 amino acids (M1-P235)[1][2].

Formula: 102143679(Gene_ID)Q38IC7 (E21-P235)(Accession)

References: [1]Daniel Čierny, et al. Genetic variants in interleukin 7 receptor α chain (IL-7Ra) are associated with multiple sclerosis risk and disability progression in Central European Slovak population. J Neuroimmunol. 2015 May 15;282:80-4./[2]Renata Mazzucchelli, et al. Interleukin-7 receptor expression: intelligent design. Nat Rev Immunol. 2007 Feb;7(2):144-54./[3]Silvia Giliani, et al. Interleukin-7 receptor alpha (IL-7Ralpha) deficiency: cellular and molecular bases. Analysis of clinical, immunological, and molecular features in 16 novel patients. Immunol Rev. 2005 Feb;203:110-26./[4]Sarita A Y Hartgring, et al. Elevated expression of interleukin-7 receptor in inflamed joints mediates interleukin-7-induced immune activation in rheumatoid arthritis. Arthritis Rheum. 2009 Sep;60(9):2595-605.

Molecular Weight: Approximately 26.3-50 kDa due to the glycosylation.

Compound Purity: 95.50

• Artikelnummer: MEXHY-P77425-250UG
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-P77425-250UG
• Green Labware: Nein
• Verpackungseinheit: 250 μg
• Mengeneinheit: STK