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CD4, Fc Fusion, Avi-Tag, Biotin-Labeled Recombinant
CD4, Fc Fusion, Avi-Tag, Biotin-Labeled Recombinant
Artikelnummer
BPS101868-1
Verpackungseinheit
100 µg
Hersteller
BPS Bioscience
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Applications: Useful for SDS-PAGE and avidin-pull down assays.
Background: CD4 is a cell surface glycoprotein found on partially defined functional T cell subsets, including helper T cells and T-regulatory cells, peripheral monocytes and other APCs (antigen-presenting cells). The ectodomain of CD4 binds to membrane-proximal domains of MHC (major histocompatibility complex) class II molecules, while its cytoplasmic domains interact with the protein tyrosine kinase p56lck (lck) through a shared cysteine-containing motif. CD4+ T cells, or helper T cells, are a type of lymphocyte that helps coordinate the immune response against infection and disease by activating cells of the innate immune system, B-lymphocytes and cytotoxic T cells. CD4+ T cells are activated by interaction between the TCR (T- cell receptor) and its cognate peptide presented on MHC II molecules, and CD4 is a critical component of the T cell receptor complex that recognizes antigenic peptides presented by MHC II molecules, increasing its stability. CD4 is typically used as a T cell marker that allows to characterize the populations of T cells present in a sample.
Description: Recombinant human CD4, encompassing amino acids 26-396, corresponding to the extracellular domain. This construct includes an Fc-domain from IgG1 fused at the C-terminus, followed by an Avi-tag™. This protein was affinity purified.
Format: Aqueous buffer solution.
Formulation: 8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Genbank: NM_000616.5
Host Cell Line: HEK293
Purity: ≥90%
Storage Stability: At least 6 months at -80°C.
Tags: C-Terminal Avi-Tag™
Uniprot: P01730
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
Applications: Useful for SDS-PAGE and avidin-pull down assays.
Background: CD4 is a cell surface glycoprotein found on partially defined functional T cell subsets, including helper T cells and T-regulatory cells, peripheral monocytes and other APCs (antigen-presenting cells). The ectodomain of CD4 binds to membrane-proximal domains of MHC (major histocompatibility complex) class II molecules, while its cytoplasmic domains interact with the protein tyrosine kinase p56lck (lck) through a shared cysteine-containing motif. CD4+ T cells, or helper T cells, are a type of lymphocyte that helps coordinate the immune response against infection and disease by activating cells of the innate immune system, B-lymphocytes and cytotoxic T cells. CD4+ T cells are activated by interaction between the TCR (T- cell receptor) and its cognate peptide presented on MHC II molecules, and CD4 is a critical component of the T cell receptor complex that recognizes antigenic peptides presented by MHC II molecules, increasing its stability. CD4 is typically used as a T cell marker that allows to characterize the populations of T cells present in a sample.
Description: Recombinant human CD4, encompassing amino acids 26-396, corresponding to the extracellular domain. This construct includes an Fc-domain from IgG1 fused at the C-terminus, followed by an Avi-tag™. This protein was affinity purified.
Format: Aqueous buffer solution.
Formulation: 8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Genbank: NM_000616.5
Host Cell Line: HEK293
Purity: ≥90%
Storage Stability: At least 6 months at -80°C.
Tags: C-Terminal Avi-Tag™
Uniprot: P01730
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
| Artikelnummer | BPS101868-1 |
|---|---|
| Hersteller | BPS Bioscience |
| Hersteller Artikelnummer | 101868-1 |
| Green Labware | Nein |
| Verpackungseinheit | 100 µg |
| Mengeneinheit | STK |
| Wirt | Human |
| Produktinformation (PDF) |
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| MSDS (PDF) |
|
Immer für Sie da
Gernot Ensinger, M.Sc.
Laurent Haze
