Clozapine, CAS 5786-21-0

Product Description: Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a Ki of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively[1][2][3]. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM)[4].

Applications: Neuroscience-Neurodegeneration

Formula: C18H19ClN4

References: [1]Seeman P, et al. Clozapine, a fast-off-D2 antipsychotic. ACS Chem Neurosci. 2014 Jan 15;5(1):24-9./[2]Zhukovskaya NL, et al. Clozapine downregulates 5-hydroxytryptamine6 (5-HT6) and upregulates 5-HT7 receptors in HeLa cells. Neurosci Lett. 2000 Jul 21;288(3):236-40./[3]Moreno JL, et al. Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice. Psychopharmacology (Berl). 2013 Jan;225(1):217-26./[4]Zorn SH, et al. Clozapine is a potent and selective muscarinic M4 receptor agonist. Eur J Pharmacol. 1994 Nov 15;269(3):R1-2.

CAS Number: 5786-21-0

Molecular Weight: 326.82

Compound Purity: 99.97

Research Area: Neurological Disease

Solubility: DMSO : 50 mg/mL (ultrasonic)

Target: 5-HT Receptor;Adrenergic Receptor;Dopamine Receptor;mAChR

• Artikelnummer: MEXHY-14539-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-14539-10.1
• Verpackungseinheit: 10mM/1mL
• Mengeneinheit: STK