cyclo(CLLFVY), CAS 1446322-73-1

Product Description: cyclo(CLLFVY) is an inhibitor for hypoxia inducible factor-1 (HIF-1), with IC50 of 19 μM (in U2OS) and 16 μM (in MCF-7). cyclo(CLLFVY) binds to the PAS-B domain of HIF-1α, inhibits HIF-1 dimerization and transcriptional activity. cyclo(CLLFVY) downregulates the expression of hypoxia response genes, such as VEGF and CAIX, exhibits antitumor against the HIF-1 associated cancers[1].

Formula: C38H54N6O7S

References: [1]Miranda E, et al., A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells. J Am Chem Soc. 2013 Jul 17;135(28):10418-25.

CAS Number: 1446322-73-1

Molecular Weight: 738.94

Research Area: Cancer

Target: HIF/HIF Prolyl-Hydroxylase;VEGFR

• Artikelnummer: MEXHY-P10426-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-P10426-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK