E6AP-mimicking peptide

Product Description: E6AP-mimicking peptide (compound 13) is a high-affinity, selective, irreversible and potent peptide-based covalent HPV16 E6 inhibitor targeting the 16E6 oncoprotein using a cysteine-reactive acrylamide warhead. E6AP-mimicking peptide has a Ki of 17 nM. E6AP-mimicking peptide targets all residues appearing in the binding pocket of E6 to disrupt the binding interface of 16E6 and E6AP. E6AP-mimicking peptide selectively binds and crosslinks to MBP-16E6 in PBS or a protein mixture[1].

Applications: COVID-19-immunoregulation

Formula: C128H193N31O29

References: [1]Xiyun Ye, et al. Discovery of reactive peptide inhibitors of human papillomavirus oncoprotein E6. Chem Sci. 2023 Oct 25;14(44):12484-12497.

Molecular Weight: 2630.09

Research Area: Infection

Target: HPV

• Artikelnummer: MEXHY-P10428-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-P10428-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK