Filgotinib (maleate), CAS 1802998-75-9

Product Description: Filgotinib maleate (GLPG0634 maleate) is a selective, orally available JAK1 inhibitor with anti-inflammatory and antiviral activities. Filgotinib maleate can effectively inhibit the activities of JAK1, JAK2, JAK3 and TYK2 with IC50 values ​​of 10 nM, 28 nM, 810 nM and 116 nM, respectively. Filgotinib maleate also inhibits HIV-1 driven gene transcription and reduces proliferation of HIV-1 infected cells. Filgotinib maleate can be used in the study of rheumatoid arthritis and inflammatory bowel disease[1][2][3].

Applications: COVID-19-immunoregulation

Formula: C25H27N5O7S

References: [1]Van Rompaey L, et, al. Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases. J Immunol. 2013 Oct 1;191(7):3568-77./[2]Labetoulle R, et al. Filgotinib for the treatment of Crohn's disease. Expert Opin Investig Drugs. 2018 Mar;27(3):295-300./[3]Yeh, et al. "Filgotinib suppresses HIV-1–driven gene transcription by inhibiting HIV-1 splicing and T cell activation." The Journal of Clinical Investigation 130.9 (2020): 4969-4984.

CAS Number: 1802998-75-9

Molecular Weight: 541.58

Compound Purity: 99.88

Research Area: Inflammation/Immunology

Solubility: DMSO : 35 mg/mL (ultrasonic;warming;heat to 60°C)

Target: HIV;JAK

• Artikelnummer: MEXHY-18300A-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-18300A-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK