Fmoc-His(3-Me)-OH, CAS 252049-16-4

Product Description: Fmoc-His(3-Me)OH derives Histidine-associating compounds with biological activity. Fmoc-His(3-Me)OH, with Fmoc-citrulline-OH, Fmoc-His(1-Me)-OH together, forms tri-peptides and shows vasodilating effect with EC50s of 2.7-4.7 mM in 1.0 mM Phenylephrine (PE)-contracted aorta rings. Fmoc-His(3-Me)OH (resin) also makes Methyl-His-Gly-Lys (His(3-Me)-Gly-Lys), thus acts as an [Ca2+]i inhibitor. Fmoc-His(3-Me)OH methylates NAHIS02, making it unable to block the Alzheimer's Aβ channel[1][2][3].

Applications: Neuroscience-Neurodegeneration

Formula: C22H21N3O4

References: [1]Tanaka M, et al. His-Arg-Trp potently attenuates contracted tension of thoracic aorta of Sprague-Dawley rats through the suppression of extracellular Ca2+ influx. Peptides. 2009 Aug;30(8):1502-7./[2]Kumrungsee T, et al. Identification of peptides from soybean protein, glycinin, possessing suppression of intracellular Ca2+ concentration in vascular smooth muscle cells. Food Chem. 2014;152:218-24. /[3]Arispe N, et al. Efficiency of histidine-associating compounds for blocking the alzheimer's Abeta channel activity and cytotoxicity. Biophys J. 2008 Nov 15;95(10):4879-89.

CAS Number: 252049-16-4

Molecular Weight: 391.42

Compound Purity: 98.0

Research Area: Cardiovascular Disease

Solubility: 10 mM in DMSO

Target: Amino Acid Derivatives;Amyloid-β

• Artikelnummer: MEXHY-W111226-1G
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-W111226-1G
• Green Labware: Nein
• Verpackungseinheit: 1 g
• Mengeneinheit: STK