(Glp5,(Me)Phe8,Sar9) Substance P (5-11), CAS 77128-69-9

Product Description: [Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats[1][2][3].

Formula: C43H61N9O9S

References: [1]Elliott PJ, et al. Selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain by infusion of a stable substance P analogue into the ventral tegmental area. Brain Res. 1986 Jan 15;363(1):145-7. /[2]Eison AS, et al. Substance P analog, DiMe-C7: evidence for stability in rat brain and prolonged central actions. Science. 1982 Jan 8;215(4529):188-90. /[3]Placenza FM, et al. Infusion of the substance P analogue, DiMe-C7, into the ventral tegmental area induces reinstatement of cocaine-seeking behaviour in rats. Psychopharmacology (Berl). 2004 Dec;177(1-2):111-20.

CAS Number: 77128-69-9

Molecular Weight: 880.06

Compound Purity: 99.01

Research Area: Metabolic Disease; Neurological Disease; Others

Solubility: DMSO : ≥ 100 mg/mL

Target: Neurokinin Receptor

• Artikelnummer: MEXHY-P3801-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-P3801-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK