Gramicidin A, CAS 11029-61-1

Product Description: Gramicidin A is a peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis. Gramicidin A is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. Gramicidin A induces degradation of hypoxia inducible factor 1 α (HIF-1α)[1][2].

Applications: Metabolism-sugar/lipid metabolism

Formula: C99H140N20O17

References: [1]Takada Y, et al. Discovery of gramicidin A analogues with altered activities by multidimensional screening of a one-bead-one-compound library. Nat Commun. 2020 Oct 1;11(1):4935./[2]David JM, et al. Gramicidin A induces metabolic dysfunction and energy depletion leading to cell death in renal cell carcinoma cells. Mol Cancer Ther. 2013 Nov;12(11):2296-307./[3]David JM, et al. Gramicidin A blocks tumor growth and angiogenesis through inhibition of hypoxia-inducible factor in renal cell carcinoma. Mol Cancer Ther. 2014 Apr;13(4):788-99.

CAS Number: 11029-61-1

Molecular Weight: 1882.29

Compound Purity: 98.1

Research Area: Cancer; Infection

Solubility: DMSO : 100 mg/mL (ultrasonic;warming)

Target: Antibiotic;Bacterial;HIF/HIF Prolyl-Hydroxylase

• Artikelnummer: MEXHY-P2324-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-P2324-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK