Product Description: Grb2, an adapter protein, crucially connects cell surface growth factor receptors to the Ras signaling pathway. Despite no direct binding to phosphorylated EGFR, Grb2 inhibits EGF-induced transactivation of a RAS-responsive element. It acts as a dominant negative relative to GRB2, suppressing proliferative signals and potentially initiating programmed cell death. Grb2 Protein, Human (His) is the recombinant human-derived Grb2 protein, expressed by E. coli , with C-6*His labeled tag. The total length of Grb2 Protein, Human (His) is 217 a.a., with molecular weight of 25-29 kDa.
Formula: 2885(Gene_ID)P62993 (M1-V217)(Accession)
Molecular Weight: Approximately 25-29 kDa
Compound Purity: 97.60