GSK 1842799 (TFA), CAS 1005407-76-0

Product Description: GSK1842799, an alkyl-substituted biaryl amino alcohol, is a selective S1P1 modulator developed for multiple sclerosis (MS). Upon phosphorylation, GSK1842799-P exhibited subnanomolar S1P1 agonist activity with over 1000-fold selectivity over S1P3. The compound showed good oral bioavailability, rapid in vivo conversion to GSK1842799-P, and significant lymphocyte count reduction at 0.1 mg/kg. It matched FTY720 efficacy at 3 mg/kg in the mouse EAE model and achieved comparable plasma levels to FTY-720 phosphate in cynomolgus monkeys. With favorable ADME, PK/PD properties, and toxicology, GSK1842799 advanced to further clinical development[1].

Applications: Neuroscience-Neuromodulation

Formula: C24H30F9N3O6S

References: [1]Discovery of Clinical Candidate GSK1842799 As a Selective S1P1 Receptor Agonist (Prodrug) for Multiple Sclerosis

CAS Number: 1005407-76-0

Molecular Weight: 659.56

Research Area: others

Target: LPL Receptor

• Artikelnummer: MEXHY-16622A-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-16622A-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK