IL-36 alpha/IL-1F6, Mouse (153a.a)

Product Description: IL-36 alpha (IL-1F6), a subform of IL-36 family, belongs to IL-1 superfamily. IL-36 alpha mediates inflammatory response. IL-36 alpha binds to IL-36R and activates NF-κB and MAPK signaling pathways, but the activation requires N-terminal cleavage by neutrophil granule-derived proteases[1]. IL-36 alpha also binds to IL-1Rrp2 and recruit IL-1RAcP. IL-36 alpha activats the MAPK, Erk1/2 and JNK through IL-36R/IL-1RAcP[2]. IL-36 alpha/IL-1F6 Protein, Mouse (153a.a) is a recombinant mouse IL-36 alpha (R8-H160) without any tag, which is produced in E. coli.

Formula: 54448(Gene_ID)Q9JLA2 (R8-H160)(Accession)

References: [1]Zhou L,et al. Interleukin-36: Structure, Signaling and Function. Adv Exp Med Biol. 2021;21:191-210./[2]Gresnigt MS, et al. Biology of IL-36 cytokines and their role in disease. Semin Immunol. 2013 Dec 15;25(6):458-65./[3]Tao X, Song Z, Wang C, Luo H, Luo Q, Lin X, Zhang L, Yin Y, Cao J. Interleukin 36α Attenuates Sepsis by Enhancing Antibacterial Functions of Macrophages. J Infect Dis. 2017 Jan 15;215(2):321-332./[4]Niu Y, et al. IL-36α Exerts Proinflammatory Effects in Aspergillus fumigatus Keratitis of Mice Through the Pathway of IL-36α/IL-36R/NF-κB. Invest Ophthalmol Vis Sci. 2021 Apr 1;62(4):16./[5]Ramadas RA, et al. IL-36α exerts pro-inflammatory effects in the lungs of mice. PLoS One. 2012;7(9):e45784.

Molecular Weight: Approximately 16 kDa

Compound Purity: 95.0

• Artikelnummer: MEXHY-P72547-2UG
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-P72547-2UG
• Green Labware: Nein
• Verpackungseinheit: 2 μg
• Mengeneinheit: STK