Product Description: Klotho-derived peptide 1 (KP1 human) blocks TGF-β/TGF-β receptor 2 interaction, inhibits TGF-β-induced activation of Smad2/3 and mitogen-activated protein kinase (MAPK), and exhibits anti-fibrotic and kidney protective effects in mouse model[1].
Applications: COVID-19-immunoregulation
Formula: C149H203N39O43
References: [1]Yuan Q, et al., A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-β signaling. Nat Commun. 2022 Jan 21;13(1):438.
Molecular Weight: 3228.44
Research Area: Inflammation/Immunology
Target: p38 MAPK;TGF-beta/Smad