Product Description: MGCD-265 analog is a potent and oral active inhibitor of c-Met and VEGFR2 tyrosine kinases, with IC50s of 29 nM and 10 nM, respectively. MGCD-265 analog has significant antitumor activity[1].
Applications: Cancer-Kinase/protease
Formula: C26H20FN5O2S2
References: [1]Claridge S, et al. Discovery of a novel and potent series of thieno[3,2-b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases. Bioorg Med Chem Lett. 2008 May 1;18(9):2793-8.
CAS Number: 875337-44-3
Molecular Weight: 517.60
Compound Purity: 98.47
Research Area: Cancer
Solubility: DMSO : ≥ 100 mg/mL
Target: Apoptosis;c-Met/HGFR;VEGFR