Nicergoline, CAS 27848-84-6

Product Description: Nicergoline, an ergoline derivative ester of bromonicotinic acid, is a potent, selective and orally active antagonist of α1A-adrenoceptor. Nicergoline has vasodilator effects. Nicergoline also has ameliorative effects on cognitive function in mouse models of Alzheimer's disease[1][2].

Applications: Neuroscience-Neuromodulation

Formula: C24H26BrN3O3

References: [1]Alvarez-Guerra, M., N. Bertholom, and R.P. Garay, Selective blockade by nicergoline of vascular responses elicited by stimulation of alpha 1A-adrenoceptor subtype in the rat. Fundam Clin Pharmacol, 1999. 13(1): p. 50-8./[2]Zang G, et, al. Ameliorative effect of nicergoline on cognitive function through the PI3K/AKT signaling pathway in mouse models of Alzheimer's disease. Mol Med Rep. 2018 May;17(5):7293-7300./[3]Mizuno T, et, al. Protective effects of nicergoline against neuronal cell death induced by activated microglia and astrocytes. Brain Res. 2005 Dec 20;1066(1-2):78-85.

CAS Number: 27848-84-6

Molecular Weight: 484.39

Compound Purity: 99.06

Research Area: Neurological Disease; Cardiovascular Disease

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Adrenergic Receptor

• Artikelnummer: MEXHY-B0702-25
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-B0702-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK