NVP-AEW541, CAS 475489-16-8

Product Description: NVP-AEW541 (AEW541 ) is an orally active inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with an IC50 value of 0.15 μM. NVP-AEW541 also inhibits InsR, IC50 with a value of 0.14 μM. NVP-AEW541 has antitumor activity[1].

Applications: Cancer-Kinase/protease

Formula: C27H29N5O

References: [1]García-Echeverría C, et al. In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase. Cancer Cell. 2004 Mar;5(3):231-9./[2]Tanno B, et al. Down-regulation of IGF-1 receptor activity by NVP-AEW541 has an antitumor effect on neuroblastoma cells in vitro and in vivo. Clin Cancer Res. 2006, 12(22), 6772-6780.

CAS Number: 475489-16-8

Molecular Weight: 439.55

Compound Purity: 99.92

Research Area: Cancer; Endocrinology

Solubility: DMSO : 50 mg/mL (ultrasonic)

Target: Autophagy;IGF-1R;Insulin Receptor

• Artikelnummer: MEXHY-50866-25
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-50866-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK