OX-201, CAS 2460722-03-4

Product Description: OX-201 is a selective agonist for OX2R with an EC50 of 8 nM. Pathological proteins produced by neurons are released into the interstitial fluid (ISF) in a manner dependent on neuronal activity and are cleared from the brain via lymphatic pathways. The outflow of pathological proteins to the ISF is related to the arousal state of neurons. OX-201 can induce neuronal awakening and promote the release of tau into the hippocampal ISF. Although OX-201 does not alter hippocampal tau levels, it has potential applications for Alzheimer's disease (AD) associated with sleep/wake rhythm disturbances[1].

Formula: C22H23F5N2O4S

References: [1]Terada M, et al. Effects of an OX2R agonist on migration and removal of tau from mouse brain. Sci Rep. 2024 Jul 10;14(1):15964.

CAS Number: 2460722-03-4

Molecular Weight: 506.49

Research Area: Neurological Disease

Target: Orexin Receptor (OX Receptor)

• Artikelnummer: MEXHY-162712-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-162712-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK